Protein Kinase Cδ Mediates Retinoic Acid and Phorbol Myristate Acetate-induced Phospholipid Scramblase 1 Gene Expression: Its Role in Leukemic Cell Differentiation Short tilte: PKCδ regulates PLSCR1 expression
نویسندگان
چکیده
Health Science Center, Shanghai Second Medical University (SSMU) -Shanghai Institutes for Biological Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai 200025, CHINA; Department of Pathophysiology, Shanghai Institute of Hematology, Rui-Jin Hospital, SSMU, Shanghai 200025, CHINA; Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA.
منابع مشابه
Protein kinase C mediates retinoic acid and phorbol myristate acetate–induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation
Although phospholipid scramblase 1 (PLSCR1) was originally identified based on its capacity to promote transbilayer movement of membrane phospholipids, subsequent studies also provided evidence for its role in cell proliferation, maturation, and apoptosis. In this report, we investigate the potential role of PLSCR1 in leukemic cell differentiation. We show that all-trans retinoic acid (ATRA), a...
متن کاملProtein kinase Cdelta mediates retinoic acid and phorbol myristate acetate-induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation.
Although phospholipid scramblase 1 (PLSCR1) was originally identified based on its capacity to promote transbilayer movement of membrane phospholipids, subsequent studies also provided evidence for its role in cell proliferation, maturation, and apoptosis. In this report, we investigate the potential role of PLSCR1 in leukemic cell differentiation. We show that all-trans retinoic acid (ATRA), a...
متن کاملNEOPLASIA Protein kinase C mediates retinoic acid and phorbol myristate acetate–induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation
Although phospholipid scramblase 1 (PLSCR1) was originally identified based on its capacity to promote transbilayer movement of membrane phospholipids, subsequent studies also provided evidence for its role in cell proliferation, maturation, and apoptosis. In this report, we investigate the potential role of PLSCR1 in leukemic cell differentiation. We show that all-trans retinoic acid (ATRA), a...
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Multiple lines of evidence have demonstrated that increased expression of phospholipid scramblase 1 (PLSCR1) is involved in the differentiation of acute myeloid leukemia (AML) cells by several differentiation-inducing agents including ATRA and phorbol 12-myristate 13-acetate. However, none of these agents can achieve nonhomogenous subcellular distribution of PLSCR1. We have demonstrated that wo...
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